My Friend's Little Sister Has It In for Me! Tomodachi no Imouto ga Ore ni dake Uzai English Subbed

For high schooler Akiteru Ooboshi, the whole youthful experience thing—like fun, friendships, and even having a girlfriend—is a complete waste of time. So when his best friend’s sister, Iroha Kohinata, keeps teasing him, Akiteru naturally finds it annoying. She practically lives in his room, she’s always on his bed, she’s just a raging storm of clinginess! Why is she only annoying around him?!

(Source: Crunchyroll)